Head and Neck Neoplasms
Conditions
Keywords
neoplasms (squamous cell carcinoma of the head and neck region)
Brief summary
The purpose of this trial is to study fluorodeoxyglucose-positron emission tomography (FDG-PET)-based dose escalation using intensity modulated radiation therapy (IMRT).
Detailed description
The dose escalation, based on the FDG-PET signal, is incorporated in the first ten fractions of the radiotherapeutic treatment. The total amount of fractions is 32, equal to a standard radiotherapeutic treatment for these types of cancers.
Interventions
PROCEDUREFDG-PET-based dose escalation using intensity modulated radiation therapy (IMRT).
FDG-PET-based dose escalation using intensity modulated radiation therapy (IMRT).
Sponsors
Belgian Federation Against Cancer
University Hospital, Ghent
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with a proven histological squamous cell carcinoma of the larynx (only T3-4 NO or Tany N+), hypopharynx, oropharynx * Patients who did not undergo surgery for the primary tumor location * Patients with a Karnofsky performance score of 70% or more * Written informed consent for participation in this trial
Exclusion criteria
* Other malignancy except for non-melanoma skin cancer * Prior irradiation to the head and neck region
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute toxicity during radiotherapy until 3 months after the end of the radiotherapy | until 3 months after the end of the radiotherapy |
| Observation of chronic toxicity | until 3 months after the end of the radiotherapy |
Secondary
| Measure | Time frame |
|---|---|
| Therapy response (2-4 months after end of radiotherapy) | 2-4 months after end of radiotherapy |
| Local control at 2 years | at 2 years |
| Pattern of recurrence | at 2 years |
Countries
Belgium
Outcome results
None listed