Hypercholesterolemia
Conditions
Brief summary
The purposes of this study are to determine: * The safety of the study medication and any side effects that might be associated with it * Whether the study medication can help patients with high levels of bad cholesterol (low-density lipoprotein-cholesterol \[LDL-C\]), alone or in combination with additional study medication
Interventions
Sponsors
Eli Lilly and Company
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Men and women between 18 and 80 years of age * People with abnormal cholesterol levels
Exclusion criteria
* People with diabetes * People whose blood pressure \>160/95 mm Hg, on or off blood pressure medicine * People who have had frequent chest pain or unstable angina, a heart attack or a heart procedure including stent placement, within the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects on bad cholesterol, LDL-C, after 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate safety after 12 weeks | — |
| Effects on other lipids and biomarkers associated with atherosclerosis after 12 weeks | — |
| Evaluate interaction of the 2 different study medications | — |
Countries
United States
Outcome results
None listed