The Timing of Prophylactic Antibiotics in Cesarean Section and the Risk of Post-operative Febrile Morbidity

Status

Terminated

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00133029

Enrollment

Unknown

Registered

2005-08-22

Start date

2004-07-31

Completion date

2006-07-31

Last updated

2016-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean Section

Brief summary

The purpose of this study is to determine whether the timing of prophylactic antibiotic administration for cesarean section (immediate preoperative versus intraoperative administration) impacts the rate of postoperative febrile morbidity. The specific aim of the project is to test the hypothesis that preoperative antibiotic administration will decrease the rate of composite postoperative febrile morbidity.

Interventions

DRUGTiming of prophylactic antibiotic administration

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Inclusion criteria

* Gestational age \> 36 weeks * Ability to understand requirements of the study * Elective/non-emergent cesarean section selected as route of delivery by treating physicians

Exclusion criteria

* Known fetal anomaly * Exposure to antibiotics within 7 days of admission, including intrapartum group B streptococcal (GBS) prophylaxis * Emergent cesarean delivery (i.e. for fetal distress, maternal distress, obstetric hemorrhage) * Overt maternal intrapartum infection requiring antibiotics * Prolonged rupture of membranes (\>18 hours)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026