Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit

Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit: A Randomized, Double Blind, Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00131521

Enrollment

260

Registered

2005-08-18

Start date

2005-01-31

Completion date

2007-12-31

Last updated

2009-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation, Mucus Obstruction

Keywords

mucus obstruction, ventilator management

Brief summary

This study compares N-acetylcysteine (mucomyst) and sodium chloride to determine their efficacy in the prevention of pulmonary mucus obstruction and retention in intubated patients admitted to the surgical trauma intensive care unit (STICU).

Interventions

DRUGmucomyst

DRUGsodium chloride (saline)

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Intubated and admitted to the Surgical Trauma Intensive Care Unit (STICU) * Subjects must be eligible to start treatment within 24 hours of their initial intubation

Exclusion criteria

* Patient anticipated to be extubated within 24 hours following STICU admission * Hypersensitivity to acetylcysteine. * Pregnancy

Design outcomes

Primary

Measure	Time frame
prevention of pulmonary mucus obstruction	—

Secondary

Measure	Time frame
days of mechanical ventilation	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026