Hypertension
Conditions
Keywords
Hypertension - Drugs - Blood pressure response - Responders - pharmacogenetics
Brief summary
The principal scientific objective of the trial is to identify the factors that are associated with differential blood pressure responses between drugs. This may allow investigators to produce new hypotheses on the pathophysiology of hypertension and on the mechanisms of drug action. These factors can be of different types: * Environmental factors (sodium or alcohol intake); * Morphological (height, weight, body mass index, body surface area); * Initial blood pressure; * Electrocardiogram (ECG) parameters of left ventricular hypertrophy; * Biological parameters as the activity level of the renin angiotensin aldosterone system; * Genetic polymorphisms.
Interventions
DRUGIndapamide (T2)
1.5 mg/day during 4 weeks
DRUGPerindopril (T1)
4 mg/day during 1 week then 8 mg/day during 3 weeks
DRUGPlacebo of Perindopril (P1)
1 pill/day during 1 week then 2 pills/day during 3 weeks
DRUGPlacebo of Indapamide (P2)
1 pill/day during 4 weeks
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
25 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Participants have to be 25 to 60 years of age * Both genders * Systolic blood pressure of 140 mmHg or above; diastolic blood pressure of 90 mmHg or above. * Cardiovascular risk must not be high, to allow for two periods of 4 weeks of placebo without ethical concern.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure at the end of each 4 week treatment period | 16 weeks | Change from baseline and after each 4 week treatment period |
Countries
France
Outcome results
None listed