Cardiac Arrest
Conditions
Keywords
Out-of-hospital cardiac arrest - Vasopressin - Epinephrine
Brief summary
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but pointed out a possible increased survival rate when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare the efficacy of two successive injections of epinephrine (1 mg) with two successive injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be enrolled.
Interventions
DRUGepinephrine (1 mg/1 mL)
DRUGarginine-vasopressin (40 UI/2 mL)
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Out-of-hospital medical cardiac arrest in adult patients.
Exclusion criteria
* Traumatic cardiac arrest * Pregnancy * Patients younger than 18 years old or older than 85 years old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival at hospital admission | — |
Secondary
| Measure | Time frame |
|---|---|
| ROSC (Return of spontaneous circulation) Survival at : H24, Day 28, hospital discharge and one year Neurological status at H24 and hospital discharge. | — |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORPierre-Yves GUEUGNIAUD, MD
Hospices Civils de Lyon
Outcome results
None listed