Bacteriuria, Urinary Tract Infection
Conditions
Keywords
Bacteriuria, Urinary Catheter, Urinary tract infection, Prophylaxis, Urinary catheter removal
Brief summary
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The purpose of this study is to determine whether antibiotic prophylaxis for urinary catheter removal is useful at preventing catheter-associated urinary-tract infection.
Detailed description
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The researchers undertake a double-blind, placebo-controlled trial to assess the efficacy of single-dose therapy of trimethoprim-sulfamethoxazole or ciprofloxacin, versus placebo therapy in selected groups of surgical patients who had bladder drainage scheduled to last longer than 3 days.
Interventions
DRUGtrimethoprim-sulfamethoxazole
DRUGciprofloxacin
Sponsors
St. Antonius Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Urethral catheter in situ for at least 3 days (72h)
Exclusion criteria
* Pregnancy * Impaired renal or hepatic function (serum creatinine \> 150 mmol/l, serum transaminases \> 75 IU/l) * Fever * Symptomatic urinary tract infection * Antibiotic use ≤ 48 hours before urinary catheter removal * Allergy to trimethoprim-sulfamethoxazole or ciprofloxacin * Urologic pathology
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic bacteriuria | — |
| Asymptomatic bacteriuria | — |
Secondary
| Measure | Time frame |
|---|---|
| Antibiotic resistance patterns | — |
Countries
Netherlands
Outcome results
None listed