Cancer, Pain
Conditions
Keywords
cancer pain, breakthrough pain, methadone, dose titration, sublingual route of administration, Cancer related pain, currently taking narcotics
Brief summary
A dose titration protocol for sublingual methadone hydrochloride for the management of cancer-related breakthrough pain to find the optimal dose.
Detailed description
This is a dose titration protocol for sublingual methadone hydrochloride for the management of cancer-related breakthrough pain to find the optimal dose.
Interventions
DRUGMethadone
Sponsors
Calgary Health Region
AHS Cancer Control Alberta
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 years of age * Experiences episodes of breakthrough pain which respond to opioid therapy * Controlled baseline pain * Cognitive status sufficient for accurate completion of assessment form * Willing to provide written informed consent * Ability to hold a volume of 1 cc of water under the tongue for 5 minutes
Exclusion criteria
* Currently or has received methadone during the previous week * Recent history of substance abuse * Severe respiratory impairment or other contraindications to opioids * Recently received therapies that had the potential to alter pain intensity or response to analgesics * Symptomatic anemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine optimal dose titration | — |
| Determine assessment protocol | — |
Outcome results
None listed