Sleep Deprivation
Conditions
Keywords
Diet, Chronic sleep deprivation, Weight, Cognitive impairment, Lipids, Inflammation, Resting metabolic rate, Weight Gain, Percent Body Fat, Hyperlipidemia
Brief summary
The purpose of this study is to determine whether or not a low calorie, low glycemic index diet with omega-3 fatty acid supplements can prevent some of the negative consequences of sleep deprivation.
Detailed description
This pilot study included 18 medical residents at two academic medical centers in New York City. All residents who participated in the study were assigned to work a night shift schedule for two weeks, and began the study on the morning prior to their first evening shift. The study subjects were randomly assigned to one of two groups: * Intervention diet -- consisting of 40% carbohydrates, 30% protein, and 30% fat with 2.4g of long chain fatty acid supplements (n=9) Total calories for males was 1600/day, and 1200/day for females * Control group -- ad lib diet. Main outcome measures included: * weight * resting metabolic rate * percent body fat * lipid profile * CRP * fasting glucose and insulin levels * urinary neurotransmitter levels * salivary cortisol * six cognitive tests of memory, attention, and executive function. Subjects were tested on day 1, 7, and 14 of the study.
Interventions
Sponsors
Inflammation Research Foundation, Marblehead, MA.
NeuroScience, Inc., Osceola, WI.
St. Vincent's Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
25 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Medical resident in good standing at Cabrini Medical Center or Saint Vincent's Hospital, NY. * Must be scheduled for two consecutive weeks of night shift work.
Exclusion criteria
* Febrile illness * Smoker * Food allergies of any kind * Taking any prescription medication * History of diabetes or thyroid dysfunction * Body mass index (BMI)\>30 * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting Metabolic Rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Percent Body Fat | — |
| Waist Circumference | — |
| Lipid Profile | — |
| C-reactive Protein Levels | — |
| Weight | — |
| Fasting serum insulin | — |
| Urinary neurotransmitter levels | — |
| Salivary a.m. cortisol levels | — |
| Cognitive scores on: Stroop Test, Hopkins Verbal Learning Test, Trail Making Test, Digit Span, Block Design, Dynamic Visual Acuity, Short Form 36 | — |
| Fasting serum glucose | — |
Countries
United States
Outcome results
None listed