Colorectal Cancer
Conditions
Keywords
colorectal cancer, erythropoietin, rehabilitation, physical capacity
Brief summary
The study is investigating whether randomization to perioperative darbepoetin alfa treatment improves the rehabilitation following surgery for colonic and rectal cancer.
Detailed description
Major surgery elicits a metabolic stress response that is followed by a loss of body mass, fatigue, and an impaired physical performance including a reduced work capacity. To perform ordinary daily activities many elderly people exert close to their maximum physical capacity, and even a small reduction of performance capacity may cause significant impairment in physical and social activity. Postoperative decline in strength and work capacity may thus cause previously independent living persons to become dependent upon assistance from others. Hence, it is important to avoid the postoperative reduction of physical performance and to minimize postoperative fatigue. It has been shown that Erythropoietin treatment reduces the need for blood transfusions in patients undergoing planned colonic surgery. However, the effect of Erythropoietin treatment upon postoperative rehabilitation has not yet been studied. Therefore the main hypothesis in this study is that perioperative treatment with Darbepoetin Alfa would improve the physical capacity in aspects by reducing postoperative fatigue and improve work capacity, balance and quality of life compared to placebo treatment. Furthermore, the researchers expect Darbepoetin treated patients to have fewer perioperative complications and less need for blood transfusions.
Interventions
DRUGDarbepoetin Alfa
Sponsors
Amgen
Herning Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Planned colonic and rectal surgery because of presumed cancer disease in the colon and rectum
Exclusion criteria
* Psychiatric disease or dementia * Diseases, that renders participation in the study impossible * Thromboembolic disease within the last three months * Dysregulated hypertension (systolic blood pressure\>175 mmHg and/or diastolic blood pressure\>105 mmHg) * Other diseases or causes that will contraindicate treatment with Darbepoetin Alfa * Other diseases or causes that will contraindicate further treatment with Darbepoetin Alfa * Patients that preoperatively and/or four days postoperatively have a hemoglobin concentration \> 14 g/dl * Former cancer disease * Disseminated cancer disease * Rectal cancer stage T4
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The functional capacity measured by postoperative fatigue, work capacity, balance, and quality of life | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscular strength | — |
| Weight | — |
| Body composition | — |
| Blood transfusion | — |
| Postoperative complications | — |
Countries
Denmark
Outcome results
None listed