Peritoneal Dialysis
Conditions
Keywords
vasopressin, icodextrin, cardiac output
Brief summary
During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.
Interventions
DRUGIcodextrin (dialysate)
2 liter of extraneal are given with one fill for 4 hours.
DRUGPhysioneal (dialysate) 1.36% and 2.27%
2 liter of Physioneal of 1.36% or 3.86% are given with one fill for 4 hours one two different days.
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Peritoneal dialysis patients
Exclusion criteria
* Insulin dependent diabetes mellitus * AV-fistula, cardial arrhythmia persistence, or severe cardiac and lung disease * Recent infectious disease * Severe psychiatric disease * Hypersensitivity to icodextrin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in cardiac hemodynamics. (Cardiac Output, stroke volume, pulse rate, blood pressure and total peripheral resistance) | 4 hours |
Countries
Denmark
Outcome results
None listed