Preeclampsia
Conditions
Keywords
CAPACITY trial, preeclampsia, plasma volume, sympathetic activity, hypertension, cardiovascular system
Brief summary
A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the researchers will test that effect on the total cardiovascular balance.
Detailed description
This is a randomized double-blind placebo controlled cross-over study in formerly preeclamptic women with a contracted plasma volume. The researchers will test the effect of methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history of preeclampsia and healthy controls.
Interventions
DRUGalpha methyldopa
500 mg twice a day
Sponsors
Radboud University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
DOUBLE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Primiparous * History of preeclampsia * Low plasma volume
Exclusion criteria
* Thrombophilia * Hypertension * Auto-immune disorder * Insulin dependent diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| normalized plasma volume | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| increased orthostatic tolerance | 1 month |
| normalized cardiovascular balance | 1 month |
| venous capacitance | 1 month |
Countries
Netherlands
Contacts
Primary ContactM.E.A Spaanderman, MD, PhD
Outcome results
None listed