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The Effect of Caffeine in Elderly Citizens

The Effect of Caffeine as Endurance Enhancing Drug in the Elderly

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00117520
Enrollment
30
Registered
2005-07-07
Start date
2002-07-31
Completion date
2006-03-31
Last updated
2006-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Elderly Citizens

Keywords

caffeine, endurance, postural stability, elderly

Brief summary

The study investigated the effect of caffeine on physical performance in healthy citizens aged over 70 years. The main hypothesis was that 6 mg/kg caffeine would improve cycling endurance at 65% of expected maximal heart rate.

Detailed description

Caffeine ingestion increases the endurance of young people exercising at 60%-85% of their maximal oxygen uptake, and it also seems to improve endurance as measured by repeated sub-maximal isometric contraction and decreases the rate of perceived exertion during exercise. Although caffeine increases endurance in young people, an increase in endurance may be of greater interest in the elderly as the population of older adults with a physically active lifestyle is growing rapidly or for increasing endurance fitness through an exercise or rehabilitation program. Therefore the main hypothesis was that caffeine would improve cycling endurance at 65% of expected maximal heart rate, and the secondary hypotheses were that caffeine would improve postural stability, reaction and movement times, isometric arm flexion endurance, and walking speed, and would reduce the rate of perceived exertion after 5 minutes of cycling in healthy elderly citizens.

Interventions

DRUGCaffeine

Sponsors

Herning Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Healthy elderly individuals aged over 70 years

Exclusion criteria

* Dementia or invalidating psychiatric disease * General debility, angina, or other diseases that would render participation in the test program impossible * Treatment with beta receptor blocking drugs, calcium-channel blocking drugs, digitalis, or nitroglycerine * Acute disease and injury * Diabetes * Conditions that would contraindicate caffeine ingestion or participation in the test program * Treatment with medication that interacts with caffeine * Ingestion of caffeine containing drinks and foods 48 hours before each session

Design outcomes

Primary

MeasureTime frame
endurance measured on an ergometer bicycle

Secondary

MeasureTime frame
postural stability
reactiontime
isometric endurance (armflexion)
walking speed
fatigue

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026