Lung Diseases, Obstructive
Conditions
Brief summary
The purpose of this study is to determine whether the Aridol (mannitol) challenge test can predict response to treatment with inhaled corticosteroids in COPD subjects. Subjects will undergo an Aridol test and then 3 months of treatment with inhaled corticosteroids. The effect on lung function and quality of life will then be measured and correlated with the Aridol test result.
Interventions
DRUGDry powder mannitol
DRUGBudesonide 400mcg administered via turbuhaler
DRUGIpratropium bromide 80mcg
Sponsors
Syntara
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of COPD (history, spirometry, symptoms including chronic cough and/or shortness of breath that is worse on exertion and/or excess sputum production) * Aged 45 - 80 years * Have pre-bronchodilator FEV1 \> 1.4 litres and at least 60% of predicted for height, age and gender and a post-bronchodilator FEV1 \<80% of predicted for height, age and gender * Post-bronchodilator FEV1/FVC \< 70 % * ≥ 10 pack years smoking history * As determined by the investigator, are capable and willing to: * perform all of the techniques necessary to measure lung function; * administer the dry powder mannitol. * Are capable of, and have given informed consent to, participating in this study in accordance with local regulations. * The subject must be in stable clinical condition at the time of, and for a period of 14 days prior to, their recruitment into the study. Stable clinical condition is defined as lack of: * change in sputum production (volume, colour, consistency); * increased cough; * worsening dyspnoea; * increased malaise, fatigue or lethargy; * reduction in exercise tolerance; * fever; * antibiotic treatment (for respiratory infection).
Exclusion criteria
* Investigators, site personnel directly affiliated with this study, and their immediate families. Immediate family is defined as a spouse, parent, child or sibling, whether biologically or legally adopted. * Subjects receiving treatment with inhaled corticosteroids (including combination therapies, e.g. Seretide®, Symbicort®) or oral corticosteroids within the last 6 weeks. * Subjects who have had an exacerbation or a chest infection within the 2 weeks prior to the study. * Subjects receiving antibiotic treatment for respiratory infection. * Known diagnosis of asthma or allergic rhinitis. * Myocardial infarction in the six months prior to enrolment. * Cerebral vascular accident in the six months prior to enrolment. * Ocular surgery in the three months prior to enrolment. * Abdominal surgery in the three months prior to enrolment. * Active tuberculosis (TB). * Lung cancer or any other malignancies, which are considered by the investigator as a contraindication to participating in the study. * Lung disease other than COPD (e.g. bronchiectasis). * Uncontrolled insulin-dependant or non-insulin dependant diabetes, i.e. \>10% HbA1c. * Female subjects of reproductive capability, not using a reliable form of contraception * Inability to obtain informed consent from the subject or subject's authorised representative. * Subjects who have participated in another investigative drug study parallel to, or within 4 weeks of, study entry. * Known intolerance to mannitol. * Uncontrolled hypertension - systolic blood pressure (BP) \> 200 mmHg and or diastolic BP \> 100 mmHg. * Planned pulmonary rehabilitation. * Have had major abdominal, chest or brain surgery in the three months prior to enrolment. * Have known cerebral, aortic or abdominal aneurysm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forced expiratory volume in one second (FEV1) | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of provoking stimulus causing a 15%, 12% or 10% fall in FEV1 (PD15, PD12, PD10) | — |
| Lung function values | — |
| Quality of life assessed by St. George's Respiratory Questionnaire (SGRQ)- total score | — |
| COPD clinical control scores (CCQ) | — |
| Response dose ratio (RDR) | — |
| Days on antibiotics | — |
| Days off work or days unable to carry out normal activities | — |
| Reversibility of airflow obstruction | — |
| Exacerbation frequency | — |
Countries
Australia
Outcome results
None listed