Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00115102

Enrollment

Registered

2005-06-21

Start date

2004-03-31

Completion date

2005-10-31

Last updated

2006-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Odontalgia

Keywords

Atypical odontalgia, capsaicin, pain, neuropathic pain

Brief summary

This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.

Interventions

DRUGfentanyl

DRUGS-ketamine

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Atypical odontalgia

Exclusion criteria

* BMI \> 30 * Heart conditions * Lung disease * Diseases of the liver or kidneys * Hypertension, untreated

Design outcomes

Primary

Measure	Time frame
Pain	—
Sensitivity to heat and cold	—
Sensitivity to mechanical stimuli	—

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026