Infertility, Infertility, Male
Conditions
Keywords
In Vitro Fertilization, Intracytoplasmic Sperm Injection, Oocytes, Zona Pellucida, Oolemma, Fertilization, Preimplantation Embryo Development
Brief summary
Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF). Laser-assisted ICSI differs from conventional ICSI in that a laser is used to drill a small hole through the hard outer coating surrounding an egg before the injection needle containing a single sperm is inserted into the egg. The hole eliminates compression of the egg that normally occurs with conventional ICSI, and thus may reduce the chance of damage. Laser-assisted ICSI is hypothesized to result in increased egg survival, and perhaps improved embryo quality, compared to conventional ICSI.
Interventions
PROCEDURELaser-assisted intracytoplasmic sperm injection
Sponsors
Shady Grove Fertility Reproductive Science Center
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of infertility * Scheduled for IVF with ICSI
Exclusion criteria
* Retrieval of fewer than 6 mature oocytes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oocyte survival rate 1 day after ICSI | — |
Secondary
| Measure | Time frame |
|---|---|
| normal fertilization rate 1 day after ICSI | — |
| embryo cell numbers 2 and 3 days after ICSI | — |
| embryo fragmentation rates 2 and 3 days after ICSI | — |
| embryo compaction rate through day 7 after ICSI | — |
| blastocyst formation rate through day 7 after ICSI | — |
Countries
United States
Outcome results
None listed