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Partner Notification for Chlamydia in Primary Care

Partner Notification for Chlamydia in Primary Care: Randomised Controlled Trial and Economic Evaluation

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00112255
Enrollment
214
Registered
2005-06-01
Start date
2001-03-31
Completion date
2002-12-31
Last updated
2018-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chlamydia Infections

Keywords

Chlamydia trachomatis, Chlamydia infections, Randomized controlled trials, Contact tracing, Family practice

Brief summary

The purpose of this study was to compare the effectiveness of partner notification by general practice nurses with referral to a specialist clinic for people with genital chlamydia diagnosed in a community setting. We hypothesised that referral to a specialist would be more effective in ensuring treatment of the sexual partners of infected people than the simpler nurse-led strategy.

Detailed description

Partner notification (contact tracing) is essential to the control of sexually transmitted infections. Reports of new chlamydia infections have increased by 66% in the past five years. A National Chlamydia Screening Programme in England, and increasing primary care provision of sexual health care are part of the United Kingdom Government's strategy for tackling increasing rates of sexually transmitted infections. New strategies for managing chlamydia in non-specialist settings are urgently required: genitourinary medicine clinics are failing to cope with their increasing workload; and 45% of cases detected in the chlamydia screening pilot studies were diagnosed in general practice. Partner notification involves informing the sexual partners of someone with a sexually transmitted infection of the possibility of exposure, offering them diagnosis and treatment, and providing advice about preventing future infection. In the United Kingdom, this is usually done by specialist sexual health advisers in departments of genitourinary medicine. The effectiveness of partner notification in non-specialist settings in developed countries is not known. We conducted a randomised controlled trial to compare the effectiveness of practice nurse-led partner notification with referral to a genitourinary clinic for partner notification conducted by a specialist health adviser, and to compare the resources used by each strategy. Comparisons: Partner notification at the time of receiving diagnosis and treatment by general practice nurses who received a one-day training course and ongoing support by telephone calls or visits from a specialist adviser in sexual health, compared with referral to a genitourinary medicine clinic for partner notification by a specialist adviser in sexual health.

Interventions

BEHAVIORALPractice nurse-led partner notification
BEHAVIORALReferral to specialist genitourinary clinic

Sponsors

University of Bristol
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Chlamydia trachomatis diagnosed through a population-based screening study * Chlamydia test result received at patient's general practice * Chlamydia cases diagnosed in general practice

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frame
Percentage of index cases with at least one sexual partner treated
Number of sexual partners per index case treated

Secondary

MeasureTime frame
Number of sexual partners per index case elicited during sexual history taking
Positive chlamydia test result six weeks after treatment
Adherence to advice to abstain from sexual intercourse until both partners completed treatment

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 12, 2026