Obesity, Type 2 Diabetes Prevention, Executive Function (Cognition)
Conditions
Keywords
prevention, children, diabetes, overweight, obesity, metabolic syndrome, exercise, insulin resistance, female, male, black, African-American, white, Caucasian, cognition, executive function
Brief summary
The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on risk for type 2 diabetes, fatness, fitness, blood cholesterol levels, and other cardiovascular risk factors in overweight elementary schoolchildren. The hypothesis is that the more exercise a child does, the more benefit he or she will gain in reducing the risk of diabetes and other cardiovascular diseases. An ancillary study examined effects on cognition and achievement.
Detailed description
The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on insulin response to the oral glucose tolerance test, body composition, fitness, lipid profile, inflammation and other metabolic syndrome components in overweight elementary schoolchildren. Blinded psychological assessments of cognition and achievement were obtained.
Interventions
BEHAVIORALAerobic exercise program
Vigorous intermittent physical activity in group format conducted in research gymnasium after school by research staff. Heart rate monitors documented each child's average heart rate on a daily basis. Small incentives were offered for achieving goal of \>150 bpm average HR each day and attending at least 80% of sessions (4 days/week).
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
7 Years to 11 Years
Healthy volunteers
Yes
Inclusion criteria
* Overweight, sedentary children * Black or white race * Attending specific schools in Augusta, GA area from which this study is recruiting
Exclusion criteria
* Unable to participate in testing or vigorous exercise program * Diabetes * Taking medication that would affect study results * Sibling enrolled in project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin area under the curve (oral glucose tolerance test) | 10-15 weeks |
| Body composition (% body fat, visceral fat) | 10-15 weeks |
| Aerobic fitness | 10-15 weeks |
| Cognition (Executive function) | 10-15 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Glucose (oral glucose tolerance test) | 10-15 weeks |
| Academic achievement | 10-15 weeks |
| Lipid profile | 10-15 weeks |
| Inflammation (C-reactive protein, fibrinogen) | 10-15 weeks |
| Blood pressure | 10-15 weeks |
Countries
United States
Outcome results
None listed