Non-Nicotine Agents for Smoking Cessation

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00108537

Enrollment

Unknown

Registered

2005-04-18

Start date

2003-10-31

Completion date

2005-09-30

Last updated

2008-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tobacco Use Disorder

Keywords

smoking, nicotine, drug therapy, smoking cessation

Brief summary

The primary objective of this study is to determine which is the better approach to smoking cessation in veterans: bupropion combined with transdermal nicotine or high dose nicotine replacement therapy (NRT) using transdermal nicotine combined with nicotine inhaler.

Detailed description

This study is a two-arm open-label, randomized controlled trial of bupropion combined with transdermal nicotine versus high dose NRT (transdermal nicotine and nicotine inhaler) with all subjects receiving a behavioral counseling program for smoking cessation.

Interventions

DRUGbupropion and transdermal patch

DRUGtransdermal patch and nicotine inhaler

Study design

Allocation

RANDOMIZED

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Readiness to set a quit date in the next two weeks, * Current smoking of at least 15 cigarettes a day

Exclusion criteria

* Current untreated depression or receiving treatment for depression, * History of seizures, major head injury, or other predisposition for seizures

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026