The Effects of Risperidone and Olanzapine on Thinking

The Cognitive Effects of Risperidone and Olanzapine

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00108368

Enrollment

Unknown

Registered

2005-04-15

Start date

2003-10-31

Completion date

2006-03-31

Last updated

2009-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychotic Disorders, Schizophrenia

Keywords

schizophrenia, cognition, antipsychotic medication, information processing, social cognition, Psychotic

Brief summary

The goal of this research is to find ways to maximize the benefits of antipsychotic medications for cognition. Hypothesis: Risperidone and olanzapine will show greater benefits than conventional medications on assessments of social cognition, particularly affect perception and social perception.

Interventions

DRUGRisperidone

DRUGOlanzapine

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Diagnosed with schizophrenia disorder by a DSM IV. * Competent to sign informed consent * No history of poor response to Risperdal and Zyprexa * No organic brain disease

Exclusion criteria

* Mental retardation or any chronic medical illness which results in the patient not being appropriate for a switch to Risperdal or Zyprexa.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 6, 2026