Brain Reaction to Treatment of Nicotine Dependence

Neural Substrates of Treatment for Nicotine Dependence

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00108173

Enrollment

104

Registered

2005-04-15

Start date

2002-10-31

Completion date

2011-06-30

Last updated

2013-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nicotine Dependence

Keywords

Position Emission Tomography (PET), Nicotine dependence, functional magnetic resonance imaging, cigarette cues

Brief summary

The purpose of the study was to determine how the treatments for cigarette craving work. Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

Detailed description

PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.

Interventions

DRUGZyban

Study design

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Heavy smoker, more than one pack per day * Free of medical conditions or medications that affect brain activity * Not pregnant

Exclusion criteria

Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

Design outcomes

Primary

Measure	Time frame	Description
2-FA PET scan results	Within the first few weeks of study initiation	Brain activity and activation in response to cigarette-related cues

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026