Glaucoma, Ocular Hypertension
Conditions
Keywords
Ocular hypertension (excessive pressure in the eye)
Brief summary
This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.
Interventions
DRUGMK0507A, dorzolamide hydrochloride (+) timolol maleate
DRUGDuration of Treatment: Part 1) 6 wk timolol maleate run in
DRUGPart 2) 6 wk washout pd Part 3) two 8 wk active tx pds
Sponsors
Merck Sharp & Dohme LLC
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with glaucoma or ocular hypertension
Exclusion criteria
* Other eye conditions * Poor vision * Recent eye surgery * Use of contact lenses * Nursing or pregnant women * Use of some other selected medications * Drug or alcohol abuse * Asthma * Slow heart beat * Allergy or previous reaction to study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hour diurnal IOP reduction after 8 weeks of treatment | After 8 weeks of treatment |
Secondary
| Measure | Time frame |
|---|---|
| IOP reduction a) from baseline at 6 weeks; b) comparison with timolol; c) comparison day versus night | At 6 weeks |
Outcome results
None listed