Osteoarthritis: Weakness From Inflammation

Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00104312

Enrollment

Registered

2005-02-25

Start date

2001-04-30

Completion date

2009-05-31

Last updated

2009-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Keywords

Knee Osteoarthritis, Muscle, Cytokine, Mobility, Function

Brief summary

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Detailed description

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure. This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery. Participation in this study is entirely voluntary.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* 50 years of age or older * Normal body weight (a Body Mass Index (BMI) of 30 or less) * Osteoarthritis of the knee (prior to knee surgery) * Planning to have knee surgery at a MedStar Hospital

Exclusion criteria

* History of a stroke * History of muscle weakness or paralysis * History of Rheumatoid Arthritis or * Inflammatory Joint Disease * History of a Bleeding Disorder * History of Gout * Diabetes for which you take insulin * Polymyalgia rheumatica (total body muscle aching/stiffness)

Countries

United States

Outcome results