Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome

Central Nervous System Modulation of Visceral Pain in Persian Gulf War Syndrome

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00100425

Enrollment

Unknown

Registered

2004-12-31

Start date

2000-09-30

Completion date

Unknown

Last updated

2009-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome

Keywords

Irritable Bowel Syndrome, Visceral Hypersensitivity, Visceral Pain

Brief summary

The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes chronic abdominal pain. The effects of dextromethorphan, naloxone, and fentanyl on experimental pain stimuli will be tested in these studies to better understand what causes irritable bowel syndrome.

Interventions

PROCEDUREViceral Perception Testing

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 72 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with irritable bowel syndrome and healthy pain-free individuals (as controls) will be studied. * No medical condition that would contraindicate use of dextromethorphan, fentanyl or naloxone.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026