Herbal Treatment for Attention Deficit Hyperactivity Disorder (ADHD)

Controlled Trial of an Herbal Treatment for Juvenile Attention Deficit Hyperactivity Disorder

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00100295

Enrollment

Registered

2004-12-29

Start date

2005-02-28

Completion date

2006-11-30

Last updated

2007-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attention Deficit Hyperactivity Disorder

Keywords

Adolescent, Child, Phytotherapy

Brief summary

The purpose of this study is to determine the safety and effectiveness of an herbal product for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents.

Detailed description

ADHD is a common childhood disorder associated with concentration problems and disruptive behavior. Evidence suggests that herbal remedies may be as effective as standard drug therapies in treating ADHD symptoms. This study will determine the safety and efficacy of an herbal treatment in children and adolescents with ADHD. This study will last 9 weeks. Participants will be randomly assigned to receive either an herbal product or placebo three times a day for the duration of the study. Participants will come in for weekly study visits at which their ADHD symptoms and any side effects will be assessed by self-report rating scales.

Interventions

DRUGHypericum perforatum

300 mg capsule taken three times a day

OTHERPlacebo

300 mg given three times a day, containing rice protein powder

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

6 Years to 17 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of ADHD * Score of greater than 1.5 standard deviation above the age and gender norms on the ADHD-IV rating scale * Parents and children can understand English * Parents and children willing to attend all study visits * Able to swallow study medication * Willing to use acceptable methods of contraception

Exclusion criteria

* Severe depression * History of bipolar disorder, psychosis, severe conduct disorder, or other serious medical conditions * Use of medications that may interact with the herbal product * Current use of medications to treat ADHD * Previous use of Hypericum * Pregnancy

Design outcomes

Primary

Measure	Time frame
side effects scale	Freqency of events during entire study
ADHD-IV rating scale	Difference between baseline and end of study

Secondary

Measure	Time frame
Child Behavior Checklist, Youth Self Report Form	Baseline and end of study

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 5, 2026