A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients

Screening Evaluations for Neurologic Syndromes: Olfactory Testing in Relatives of Parkinson's Disease Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00096876

Enrollment

600

Registered

2004-11-17

Start date

2004-10-31

Completion date

2008-06-30

Last updated

2019-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease, Parkinsonian Syndrome

Keywords

Parkinsonian syndrome

Brief summary

In this study, individuals complete and return a mail survey, specifically a 40 item scratch and sniff smell test.

Detailed description

This study would extend the findings of previous studies by characterizing the performance of the 40-item UPSIT in a cohort of first-degree relatives of Parkinson's disease (PD) patients. The results would also validate the use of the University of Pennsylvania Smell Identification Test (UPSIT) as a mail-survey instrument. Once identified, these individuals could be followed as a potentially at-risk cohort to determine if the screening evaluation was predictive of later developing Parkinson's disease. The results from this pilot study have the potential to guide the use of olfactory testing using the UPSIT as a screening tool, and to provide necessary preliminary data for planning clinical trials to prevent the occurrence of PD in at-risk individuals.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Subject must be a first-degree relative of a PD patient with diagnosis confirmed by a movement disorders specialist at the Institute for Neurodegenerative Disorders * Subject must not carry a diagnosis of PD or other neurodegenerative disorder * Subject must be either at least 50 years old or within 10 years of the age of onset of their affected relative * Subject must be a non-smoker * Subject must have no other known reason for abnormal olfaction (e.g. nasal trauma)

Countries

United States

Outcome results