Urinary Tract Infections
Conditions
Keywords
Vaccinium macrocarpon
Brief summary
The purpose of this study is to determine whether daily consumption of cranberry juice lessens the symptoms and prevents the recurrence of urinary tract infections (UTIs). This study will also determine whether drinking cranberry juice for 6 months selects for less virulent bacteria in the rectal, vaginal, and urethral areas.
Detailed description
Participants in this study will be randomly assigned to consume either 8 ounces of cranberry juice or placebo juice twice a day for 6 months. Participants will have follow-up visits at 3 and 6 months, and whenever they experience a symptomatic episode. Urine, vaginal and rectal specimens will be taken at each visit to test for the presence of bacteria that cause urinary tract infections. Participants will complete a questionnaire at study entry, Day 3, Weeks 1 and 2, and monthly thereafter or whenever there is a recurrence of symptoms.
Interventions
DRUGCranberry juice
TID dosage for UTI treatment
DIETARY_SUPPLEMENTPlacebo cranberry juice
TID placebo dosage to match active comparator
Sponsors
National Center for Complementary and Integrative Health (NCCIH)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Culture-confirmed urinary tract infection at study start
Exclusion criteria
* Other chronic disease * Antibiotics within 48 hours prior to study start * Hospitalization for any reason within 2 weeks prior to study start * Stones in urinary tract * Plans to leave Ann Arbor within 6 months after study start * Allergy to cranberry or cranberry compounds * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Culture | per visit |
Countries
United States
Outcome results
None listed