Healthy Volunteer
Conditions
Keywords
Cerebrospinal Fluid, Stool, Urine, Natural History, Skin, Sputum, Healthy Volunteer, HV
Brief summary
Increased numbers of white blood cells called eosinophils can cause disease. To investigate this disease, researchers need blood, urine, sputum, stool, cerebrospinal fluid, skin and/or bone marrow samples to compare to samples from patients with this problem. Some of the samples will be used for genetic testing or future research. This study will last for about 10 years and will include a maximum of 50 paid volunteers ages 18 to 65.
Detailed description
This protocol is designed to provide data and samples from paid volunteers for use in translational studies of eosinophilia and parasitic diseases. Donors meeting standard normal donor eligibility criteria will be recruited to undergo research procedures (infrared thermography and/or esophageal string test) and/or to donate blood, body fluid and/or tissue samples obtained using conventional techniques. The investigational nature of the studies in which their data and/or samples will be used, as well as the risks and benefits of the procedures, will be explained to all volunteers, and a signed informed consent document will be obtained. Volunteers will be compensated according to an established schedule based on the duration and discomfort of the donation. Samples provided through this protocol will be used solely for in vitro research and will be assigned a unique product number. The study investigators listed on this protocol will serve as the custodians of the code that links the product with a donor s identity. The nature of the in vitro studies in which the data and specimens collected in this study will be used is not the subject of this protocol and will be described in general terms only, since it involves several IRB-approved LPD protocols. Because some of these protocols require normal controls without a history of asthma or allergic disease, all subjects will undergo a standardized allergy/asthma history at enrollment. Serum immunoglobulin levels and a basic RAST panel may be performed on sera from some normal donors, and some normal donors may be asked to undergo pulmonary function testing.
Interventions
None listed
Sponsors
National Institute of Allergy and Infectious Diseases (NIAID)
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Eligibility criteria for volunteer whole blood donation are based on the Standards of the AABB and the Code of Federal Regulation 21 CFR 640. Specific criteria follow: INCLUSION CRITERIA (blood, urine, stool, infrared thermograpy, photography, gastrointestinal secretion, pulmonary function testing and/or sputum donation) * ability to sign informed consent * healthy male or female * 18-85 years of age
Exclusion criteria
(blood, urine, stool, infrared thermograpy, photography, gastrointestinal secretion, pulmonary function testing and/or sputum donation) * pregnancy * weight \<110 pounds * history of heart, lung, kidney disease, chronic anemia or bleeding disorders Eligibility for tissue biopsy donation (other than skin) will be determined by the protocol under which the procedure is performed and the physician performing the procedure. Eligibility criteria for volunteer bone marrow, skin and cerebrospinal fluid donation are more stringent than those for other specimen donations to minimize risk of procedure complications and maximize utility of specimens for study: INCLUSION CRITERIA (bone marrow, cerebrospinal fluid and/or skin donation) * ability to sign informed consent * healthy male or female * 18-65 years of age * willingness to provide concurrent blood sample
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| - To provide an IRB-approved mechanism for the collection of peripheral blood, urine, sputum, stool, cerebrospinal fluid, skin biopsy and bone marrow samples from paid, volunteer donors for use in in vitro studies. | 50 years | \- To provide adequate and complete informed consent to the donors of research blood samples, and to assure that the education, counseling and protection of the study subjects from research risks is performed in accordance with IRB, OHRP, and other applicable Federal regulatory standards. |
Countries
United States
Contacts
CONTACTThomas W Brown, R.N.
CONTACTAmy D Klion, M.D.
PRINCIPAL_INVESTIGATORAmy D Klion, M.D.
National Institute of Allergy and Infectious Diseases (NIAID)
Outcome results
None listed