Lymphoma
Conditions
Keywords
primary central nervous system non-Hodgkin lymphoma
Brief summary
RATIONALE: Monoclonal antibodies, such as rituximab and yttrium Y 90 ibritumomab tiuxetan, can locate cancer cells and either kill them or deliver radioactive cancer-killing substances to them without harming normal cells. PURPOSE: This clinical trial is studying how well giving yttrium Y 90 ibritumomab tiuxetan together with rituximab works in treating patients with recurrent primary CNS lymphoma.
Detailed description
OBJECTIVES: Primary * Determine the absorbed radiation doses of CNS lesions after administration of indium In 111 ibritumomab tiuxetan (for imaging) in patients with recurrent primary CNS lymphoma. Secondary * Determine the safety of a therapeutic dose of yttrium Y 90 ibritumomab tiuxetan in these patients. Tertiary * Determine the radiographic response in patients treated with this drug. OUTLINE: Patients receive rituximab IV on day 1. Within 4 hours after rituximab administration, patients receive indium In 111 ibritumomab tiuxetan IV over 10 minutes. Patients then undergo whole body imaging. Patients whose dosimetry indicates that their CNS lesion would receive a sufficient radioimmunotherapy dose receive a therapeutic dose of yttrium Y 90 ibritumomab tiuxetan IV over 20-30 minutes on day 7. Patients are followed monthly for 3 months, every 3 months for 2 years, and then every 6 months for 2 years. PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
Interventions
BIOLOGICALrituximab
RADIATIONyttrium Y 90 ibritumomab tiuxetan
Sponsors
National Cancer Institute (NCI)
Memorial Sloan Kettering Cancer Center
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically confirmed non-Hodgkin's lymphoma (NHL) * Recurrent disease * Isolated CNS relapse of systemic NHL allowed * Primary CNS lymphoma * Measurable gadolinium-enhancing lesion on MRI of the brain * No impaired bone marrow reserve * No hypocellular bone marrow * No marked reduction in bone marrow precursors of one or more cell lines (granulocytic, megakaryocytic, erythroid) * No pleural effusion * No chronic lymphocytic leukemia * No AIDS-related lymphoma PATIENT CHARACTERISTICS: Age * Adult Performance status * Not specified Life expectancy * Not specified Hematopoietic * Platelet count \> 100,000/mm\^3 * Absolute neutrophil count ≥ 1,500/mm\^3 Hepatic * Bilirubin ≤ 2.0 mg/dL Renal * Creatinine ≤ 2.0 mg/dL Other * HIV negative * No serious nonmalignant disease that would preclude study participation * No infection * No anti-murine antibody reactivity\* * No human anti-mouse antibodies * Not pregnant * Negative pregnancy test NOTE: \*Results must be available prior to study entry for patients who received prior murine antibodies or proteins, other than rituximab PRIOR CONCURRENT THERAPY: Biologic therapy * See Radiotherapy * No prior stem cell transplantation * No prior myeloablative therapies with autologous bone marrow transplantation or peripheral blood stem cell rescue * No prior failed stem cell collection * More than 2 weeks since prior filgrastim (G-CSF) or sargramostim (GM-CSF) Chemotherapy * No more than 1 prior chemotherapy regimen Endocrine therapy * Not specified Radiotherapy * No prior radioimmunotherapy * No prior whole-brain radiotherapy * No prior external beam radiotherapy (involved field or regional) to \> 25% of active bone marrow Surgery * More than 4 weeks since prior major surgery except diagnostic surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosimetry at 1, 24, and 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety by NCI common toxicty criteria | — |
| Radiographic response at 1 and 3 months | — |
Countries
United States
Outcome results
None listed