HIV Infections
Conditions
Keywords
HIV, Marijuana, Marinol, Oral THC, Appetite, Complementary Therapies
Brief summary
Smoked marijuana (MJ) and dronabinol (also known as THC or by the trade name Marinol) are used to increase appetite, food intake, and weight in patients with HIV who experience unintended weight loss. This study will compare the effects of MJ and Marinol use in marijuana smokers who are HIV infected.
Detailed description
Little is known about the efficacy and tolerability of oral THC versus smoked MJ in a clinically relevant population. Additionally, it is not clear how THC's effects vary as a function of the duration of treatment or the patient's current patterns of smoked MJ use. This study directly compares 3 doses of smoked marijuana and 3 doses of Marinol across a range of behavioral measures in HIV infected marijuana smokers. Outcome measures will include analysis of food intake, body composition, mood, physical symptoms (e.g., nausea, stomach pain), psychomotor task performance, and sleep.
Interventions
DRUGdronabinol
dronabinol to prevent development of marijuana withdrawal
Sponsors
National Institute on Drug Abuse (NIDA)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* HIV infected * Smoke marijuana * Taking HIV medications
Exclusion criteria
* Naive marijuana smokers * People with history of respiratory/pulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| daily caloric intake | daily measure of colories |
Countries
United States
Outcome results
None listed