ABI-007 in Treating Patients With Chemotherapy-Naïve Stage IV Non-Small Cell Lung Cancer

Inclusion criteria

DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed stage IV non-small cell lung cancer * Evidence of inoperable local recurrence or metastasis * Bone metastases or other nonmeasurable disease may not be only evidence of metastasis * Measurable disease documented radiographically * No evidence of active brain metastases or leptomeningeal involvement PATIENT CHARACTERISTICS: Age * 18 and over Performance status * ECOG 0-1 OR * Karnofsky 80-100% Life expectancy * More than 12 weeks Hematopoietic * Absolute neutrophil count ≥ 1,500/mm\^3 * Platelet count ≥ 100,000/mm\^3 * Hemoglobin ≥ 9 g/dL Hepatic * AST and ALT ≤ 2.5 times upper limit of normal (ULN) * Bilirubin normal * Alkaline phosphatase ≤ 2.5 times ULN (unless due to bone metastases and there is no radiologic evidence of hepatic metastases) Renal * Creatinine ≤ 1.5 mg/dL Other * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective barrier contraception for 1 month before and during study participation * No prior allergy or hypersensitivity to study drug * No other concurrent active malignancy * No pre-existing peripheral neuropathy grade 1 or greater * No other concurrent clinically significant illness * No concurrent serious medical risk factor involving any of the major organ systems that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy * Not specified Chemotherapy * No prior chemotherapy for metastatic disease * More than 4 weeks since prior cytotoxic chemotherapy * No concurrent doxorubicin * No other concurrent taxanes * No concurrent anthracyclines Endocrine therapy * Not specified Radiotherapy * At least 3 weeks since prior radiotherapy to a major bone marrow-containing area * More than 4 weeks since prior radiotherapy except to a non-target lesion * Prior radiotherapy to a target lesion allowed provided there has been clear progression of the lesion since completion of radiotherapy Surgery * Not specified Other * Prior epidermal growth factor-targeted therapy allowed * More than 4 weeks since prior investigational drugs * No concurrent enrollment in another clinical trial in which investigational drugs are administered or investigational procedures are performed * No concurrent treatment with any of the following: * Ritonavir * Saquinavir * Indinavir * Nelfinavir * No concurrent anticonvulsants * No other concurrent anticancer drugs * No other concurrent investigational drugs