HIV Infections
Conditions
Keywords
HIV Preventive Vaccine, HIV Seronegativity, Protein
Brief summary
The purpose of this study is to determine the safety of a new HIV vaccine. The vaccine in this study is mixed with a chemical called alum to improve the body's response to the vaccine. Healthy adults who are not infected with HIV may participate in the study.
Detailed description
EnvPro is a recombinant, purified envelope protein vaccine with an aluminum hydroxide (alum) adjuvant. Aluminum hydroxide is licensed as an adjuvant in other vaccines, such as the hepatitis B vaccine. This study will examine the safety and tolerability of EnvPro with alum adjuvant in healthy, HIV uninfected adults. All participants in this study will receive vaccine injections in the upper arm muscle. Participants will receive a second vaccine injection eight weeks after the first injection. Blood tests will be performed at study visits before the vaccine is given, during the eight weeks between injections, and at selected times for up to three years after the vaccine is given.
Interventions
BIOLOGICALEnvPro
Sponsors
National Institute of Allergy and Infectious Diseases (NIAID)
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* HIV uninfected * Normal medical history and physical exam * Normal complete blood count * Normal liver function * Normal renal function * Normal serum creatine phosphokinase (CPK) * Availability for at least 1 year follow-up
Exclusion criteria
* History of immunosuppressive illness, chronic illness, or use of any immunosuppressive medications * Medical or psychiatric condition or occupational responsibilities which preclude compliance with the study * Live attenuated vaccines within 60 days of study entry * Use of experimental agents within 30 days of study entry
Countries
United States
Outcome results
None listed