Depression
Conditions
Keywords
Adolescent
Brief summary
This study examines the impact of a group cognitive behavioral program aimed at preventing depressive disorders and symptoms in adolescents at risk for developing depression.
Detailed description
Depression is a prevalent, chronic, and impairing condition that is often undetected and becomes more difficult to treat as chronicity increases. There is an increasing need to conduct large-scale depression prevention studies in adolescents. This study evaluates a cognitive-behavioral prevention (CBP) program to determine its effectiveness in preventing depressive disorders in at-risk adolescents. The study also will ascertain the costs this intervention to inform attempts at future dissemination of the program in real world settings. Participants in this study are randomly assigned to receive either CBP for eight weekly and 6 monthly continuation sessions or usual care. Depressive symptoms and disorders, levels of functioning, and medical and mental health care utilization are assessed at baseline and again at 2, 8, 20, and 32 months after intake.
Interventions
BEHAVIORALCognitive-behavioral prevention program
Cognitive-behavioral prevention program includes 8 weekly and 6 monthly group sessions.
OTHERUsual care
Participants receive usual care
Sponsors
National Institute of Mental Health (NIMH)
Vanderbilt University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Masking description
Outcome assessor were unaware of condition assignment
Eligibility
Sex/Gender
ALL
Age
13 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* A parent has had a depressive disorder during child's life * Adolescent has had a past depressive episode or has current subsyndromal depressive symptoms measured on the Center for Epidemiological Studies Depression Scale (CES-D)
Exclusion criteria
* adolescent or parent ever diagnosed with bipolar I or schizophrenia; * adolescent has a current DSM-IV mood disorder diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Onset of a probable or definite depressive episodes (i.e., Depression Symptom Rating greater or equal to 4) | Time to a score of 4 or higher between baseline and 9 months using survival analysis | a score of 4 or greater is considered an onset |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of depression-free days | Measured continuously through Month 33 | Using the depression symptom ratings (DSR) (1-6), each week is given a score of 1 to 6; depression-free days are those with ratings of 1 or 2 on the DSR. |
Countries
United States
Outcome results
None listed