Rheumatoid Arthritis
Conditions
Keywords
Genetics
Brief summary
Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.
Detailed description
The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families. This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.
Interventions
None listed
Sponsors
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis Foundation
Northwell Health
Study design
Observational model
FAMILY_BASED
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult onset RA * Diagnosis of RA made between 18 and 60 years old * Both parents alive and willing to participate * Parents may have diagnosis of RA (affected) or be unaffected
Exclusion criteria
* Inflammatory bowel disease * Lupus * Psoriatic arthritis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic Association with risk for rheumatoid arthritis | 10 years | The project aims to identify risk alleles for rheumatoid arthritis using association methods in trio families, combined with data from singleton cases and multiplex families |
Countries
United States
Outcome results
None listed