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Exercise Training in Obesity-prone Black and White Women

Exercise Training in Obesity-prone Black and White Women

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00067873
Enrollment
231
Registered
2003-09-01
Start date
2000-12-31
Completion date
2007-12-31
Last updated
2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Brief summary

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Detailed description

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance. Time of initial weight loss was defined as the time needed to reach the goal of 25 kg/m2 BMI. The women will then be evaluated one year after this time and the amount of weight gain will be determined.

Interventions

BEHAVIORALDiet
BEHAVIORALAerobic exercise
BEHAVIORALResistance exercise

Sponsors

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
CollaboratorNIH
University of Alabama at Birmingham
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
21 Years to 41 Years
Healthy volunteers
Yes

Inclusion criteria

* Normoglycemic * BMI between 27-30 * Non smoker * Premenopausal * Physically untrained * Family history of obesity

Design outcomes

Primary

MeasureTime frameDescription
Weight loss6 months
Change in weight after initial weight loss12 months after initial weight loss (maximum 18 months after randomization)Time of initial weight loss determined by days to reach BMI \<= 25 (maximum 6 months)

Secondary

MeasureTime frame
Change in cholesterol6 months post baseline
Insulin sensitivity6 months post baseline
Change in resting energy expenditure6 months post baseline
Change in triglycerides6 months post baseline
Change in visceral fat6 months post baseline

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 25, 2026