HIV Infections
Conditions
Keywords
HIV, DHEA, immune system, hormones, body composition, quality of life
Brief summary
This study's purpose is to learn how dehydroepiandrosterone (DHEA) affects the HIV virus, the immune system, hormone levels, body composition and quality of life.
Interventions
DRUGDHEA
Sponsors
National Center for Complementary and Integrative Health (NCCIH)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Evidence of HIV-1 infection * HIV RNA \<50 copies/mL * Stable antiretroviral treatment regimen for at least 8 weeks * Age 18 years or older * Normal pap smear and mammograph within 1 year (females) * Normal prostate-specific antigen level with in one year, age adjusted (males)
Exclusion criteria
* Active opportunistic infections or malignancy other than localized cutaneous KS lesions * Concurrent or prior use within the past 8 weeks of DHA, testosterone, other anabolic steroids, corticosteroids, megestrol acetate, growth hormone, IL-2, or thalidomide * Diagnosis of AIDS Dementia Complex (stage II or higher) * Active substance abuse (e.g., alcohol or injection drugs) * Evidence of severe liver dysfunction or hepatic transaminases greater than 3x the upper normal limit * Pregnant or breast-feeding * History of endocrinologically-responsive tumors (e.g., breast, ovarian, uterine, or prostatic cancer, or malignant melanoma)
Countries
United States
Outcome results
None listed