Black Cohosh Extract in Postmenopausal Breast Health

The Effect of Black Cohosh Extract on the Human Breast

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00064831

Enrollment

Registered

2003-07-15

Start date

2003-07-31

Completion date

2007-02-28

Last updated

2007-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hot Flashes, Menopause

Keywords

estrogen stimulation, relief of hot flashes, nipple aspirate fluid, body fluid levels of black cohosh

Brief summary

The purpose of the study is to determine if black cohosh extract (BCE) administration in symptomatic postmenopausal women results in estrogenic stimulation of the breast, as determined by estradiol, pS2, FSH, LH, and PSA levels in nipple aspirate fluid.

Detailed description

As in Brief Summary

Interventions

DRUGBlack Cohosh Extract (BCE)

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* Postmenopausal females * 20 months since any breastfeeding * Active postmenopausal symptoms, i.e., hot flashes * At least 6 months since last menstrual period or have had a hysterectomy with both ovaries removed * Able to make 4 visits during the trial to the study clinic in Columbia, Missouri

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026