A Study of ABT-751 in Patients With Recurrent Breast Cancer After Taxane (Taxol or Taxotere) Therapy.

A Phase II Study of ABT-751 in Patients With Breast Cancer Refractory to Taxane Regimens

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00063102

Enrollment

Registered

2003-06-23

Start date

2002-11-30

Completion date

2004-08-31

Last updated

2007-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Brief summary

The purpose of the study is to determine if ABT-751 will decrease tumors, and determine how long the tumor shrinkage can be maintained in patients with breast cancer after having had taxol or taxotere. Patients will receive ABT-751 by mouth daily for 21 days. Patients will be off drug for 7 days before starting the next cycle of drug.

Interventions

DRUGABT-751

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Stage IIIB or IV breast cancer. * Recurrent tumor after or while on taxane therapy (taxol or taxotere). * Able to tolerate normal activities of daily living. * Adequate bone marrow, kidney and liver function.

Exclusion criteria

* Pregnant or breast feeding. * No anti-tumor therapy (including hormonal therapy or Herceptin) within 4 weeks of the start of ABT-751 administration.

Design outcomes

Primary

Measure	Time frame
Objective Response Rate in subjects with Breast cancer	1 year

Secondary

Measure	Time frame
Time to Tumor Progression (TTP)	1 year
Survival	2 years
Toxicities associated with treatment administration	1 year

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026