Congenital Abnormalities, Infant, Premature, Diseases, Perinatal Asphyxia
Conditions
Keywords
Esophageal, Airway
Brief summary
Feeding difficulties and airway related consequences contribute significantly to the infant mortality and morbidity. Some of these problems may be dependent on neural control and muscular function. Prematurity, congenital anomalies and perinatal depression represent three important conditions in infants, that may have feeding and airway difficulties.Development of motility of the foregut and the adaptation during normal and disease in developing infants is unclear.
Detailed description
With the aid of small clinical research funding from the NIDDK, in this proposal, we have developed methods to safely evaluate foregut motility in relation to breathing among high risk infants. We are using simultaneous esophageal motility studies, swallowing and respiratory measurements in this evaluation.
Interventions
None listed
Sponsors
Children's National Research Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Weeks to 6 Months
Healthy volunteers
Yes
Inclusion criteria
Prematurely born infants, Infants with congenital foregut anomalies, Infants with perinatal asphyxia, Ability to maintain vital signs at study,
Exclusion criteria
No contraindication to enteral feeding
Countries
United States
Outcome results
None listed