Treatment of Cholestatic Pruritus With Sertraline

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00058903

Enrollment

Registered

2003-04-16

Start date

2003-04-30

Completion date

2005-03-31

Last updated

2010-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis C, Liver Cirrhosis, Biliary, Pruritus

Keywords

Cholestatic, Pruritus, Sertraline, primary biliary cirrhosis, hepatitis C

Brief summary

The goal of this study is to find an effective and well-tolerated medical therapy for itching due to liver disease. Persons with primary biliary cirrhosis or chronic hepatitis C are currently being enrolled in the study. Persons participating in the study are given sertraline, a medication which is also often used for depression,to treat their itching. The dose is gradually increased as the effect on itching and any other potential side effects are carefully monitored.

Interventions

DRUGsertraline

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Itching for at least 3 months * Primary biliary cirrhosis or hepatitis C * Elevated alkaline phosphatase for at least 6 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026