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Docetaxel and Capecitabine in Treating Patients With Metastatic Cancer of the Stomach or Gastroesophageal Junction

A Phase II Study Of Docetaxel And Capecitabine In Patients With Measurable Metastatic Adenocarcinoma Of The Stomach And Gastroesophageal Junction

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00054457
Enrollment
46
Registered
2003-02-06
Start date
2003-09-30
Completion date
2008-02-29
Last updated
2016-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal Cancer, Gastric Cancer

Keywords

adenocarcinoma of the stomach, adenocarcinoma of the esophagus, stage IV gastric cancer, recurrent gastric cancer, stage IV esophageal cancer, recurrent esophageal cancer

Brief summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study of the effectiveness of combining docetaxel with capecitabine in treating patients who have metastatic cancer of the stomach or gastroesophageal junction.

Detailed description

OBJECTIVES: * Determine the objective tumor response rate in patients with metastatic gastric or gastroesophageal junction adenocarcinoma treated with docetaxel and capecitabine. * Determine the time to progression in patients treated with this regimen. * Determine the overall survival in patients treated with this regimen. * Determine the toxic effects of this regimen in these patients. * Determine whether interleukin-1 polymorphisms are present among patients who have weight loss vs no weight loss, and their relationship to a poor prognosis. * Assess the quality of life and swallowing uniscale during chemotherapy in these patients. OUTLINE: Patients receive docetaxel IV over 1 hour on day 1 and oral capecitabine twice daily on days 1-14. Courses repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, at each tumor measurement, and at the end of treatment. Patients are followed every 3 months until disease progression and then every 6 months until 3 years from registration.

Interventions

DRUGcapecitabine
DRUGdocetaxel

Sponsors

National Cancer Institute (NCI)
CollaboratorNIH
Alliance for Clinical Trials in Oncology
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed adenocarcinoma of the stomach or gastroesophageal junction * Deemed unresectable and not a candidate for potentially curative treatment (e.g., surgical resection or combined modality therapy) * At least 4 weeks since prior abdominal exploration with resection (3 weeks without resection) * No other more conventional forms of therapy available with a reasonable chance of cure or significant palliation * Measurable disease\* * The following are not considered measurable disease: * Bone lesions * Leptomeningeal disease * Ascites * Pleural/pericardial effusion * Lymphangitis cutis/pulmonis * Abdominal masses that are not confirmed and followed by imaging * Cystic lesions NOTE: \*Patients having only lesions measuring ≥ 1 cm to \< 2 cm must use spiral CT scan for all tumor assessments. * No untreated or treated but symptomatic CNS metastases PATIENT CHARACTERISTICS: Age * 18 and over Performance status * ECOG 0-2 Life expectancy * At least 12 weeks Hematopoietic * Absolute neutrophil count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 Hepatic * Bilirubin no greater than upper limit of normal (ULN) * AST no greater than 2.5 times ULN if alkaline phosphatase is less than ULN OR * Alkaline phosphatase no greater than 4 times ULN if AST less than ULN Renal * Creatinine normal * Creatinine clearance at least 60 mL/min Cardiovascular * No New York Heart Association class III or IV heart disease Other * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * Ability to swallow capecitabine * No prior anaphylactic reaction to any taxane * No prior severe reaction to fluoropyrimidine * No prior poor tolerance to capecitabine * No known sensitivity or poor tolerance to fluorouracil * No known dihydropyrimidine dehydrogenase deficiency * No uncontrolled infection * No uncontrolled seizure disorder * No chronic debilitating disease * No peripheral neuropathy of any etiology greater than grade 1 * No diabetes mellitus * No other malignancy within the past 5 years except adequately treated basal cell or squamous cell carcinoma or adequately treated noninvasive carcinoma PRIOR CONCURRENT THERAPY: Biologic therapy * No prior immunotherapy or biologic therapy for recurrent or metastatic disease * No concurrent biologic therapy Chemotherapy * No prior chemotherapy for recurrent or metastatic disease except for the following: * Adjuvant chemotherapy after complete resection of the original tumor * Neoadjuvant chemotherapy followed by surgical resection of the original tumor * No other concurrent chemotherapy Endocrine therapy * Not specified Radiotherapy * No prior radiotherapy except for the following: * Adjuvant radiotherapy after complete resection of the original tumor * Neoadjuvant radiotherapy followed by surgical resection of the original tumor * No prior radiotherapy to 25% or more of the bone marrow * More than 4 weeks since prior radiotherapy * No concurrent radiotherapy Surgery * See Disease Characteristics * No prior organ allograft Other * No concurrent brivudine or sorivudine

Design outcomes

Primary

MeasureTime frame
Proportion of successesUp to 3.5 years

Secondary

MeasureTime frame
Survival timeUp to 3.5 years
Time to disease progressionUp to 3.5 years
Duration of responseUp to 3.5 years
Time to treatment failureUp to 3.5 years
Quality of life as measured by the LASA, FACT-E and Patient Uniscale Swallowing questionnairesUp to 3.5 years

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026