Heart Failure, Congestive
Conditions
Keywords
CHF, heart, failure, congestive, enoximone, phosphodiesterase, inhibitor
Brief summary
To determine if low-dose enoximone therapy is an effective treatment for advanced chronic heart failure.
Detailed description
The study is a randomized, double-blind, multicenter, parallel group, placebo-controlled trial of oral enoximone in approximately 700 subjects with advanced chronic heart failure of either ischemic or nonischemic etiology receiving optimal conventional heart failure therapy. Eligible subjects will be randomized in a 1:1 ratio to receive either enoximone or placebo at the Randomization Visit. The initial dose of study drug will be 25 mg t.i.d.(3xday) and will be administered immediately after randomization. Subjects who tolerate this initial dose will be continued on 25 mg t.i.d. for at least two weeks. After two weeks, eligible subjects will be titrated to 50 mg t.i.d. for the duration of the study.
Interventions
DRUGEnoximone
Participants receive oral enoximone
DRUGEnoximone placebo
Participants receive placebo to match enoximone
Sponsors
Gilead Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
In order to be considered eligible subjects, the following entry criteria must be met: * At least 18 years of age * ischemic or nonischemic cardiomyopathy * NYHA Class III or IV * one hospitalization, or two outpatient visits, for the treatment of worsening heart failure within 12 months requiring the administration of I.V. heart failure therapy * LVEDD \>3.2 cm/m2 or \>=6.0 cm * LVEF of less than or equal to 30% * concomitant treatment with optimal conventional heart failure therapy
Exclusion criteria
Subjects who meet any one of the following criteria will be deemed ineligible for participation in the study: Subjects on the following concomitant medications: * Calcium antagonists other than amlodipine or felodipine * Flecainide, encainide, propafenone, dofetilide or disopyramide * Subjects receiving I.V. positive inotropic agents within seven days of the Screening Visit or Randomization Visit * Subjects receiving a human B-type natriuretic peptide, including nesiritide, within seven days of the Screening Visit or Randomization Visit * Subjects receiving oral or I.V. phosphodiesterase III inhibitors (PDEI III), including levosimendan and cilostazol, within seven days of the Screening Visit or Randomization Visit * Subjects with active hepatic (screening serum total bilirubin \>= 3.0 mg/dl (\>=51.3 umol/l), renal (screening serum creatinine \>= 2.0 mg/dl (=178.8 umol/l)), hematologic, gastrointestinal, immunologic, endocrine, metabolic, or central nervous system disease * Subjects with a serum potassium \<4.0 mEq/L or \>5.5 mEq/L (\<4.0 mmol/l or \>5.5 mmol/l) at Randomization Visit * Subjects with a magnesium level of \<1.0 mEq/L (\<0.5 mmol/l) at Randomization Visit (Visit 0) * Subjects with a serum digoxin of \>1.2 ng/ml (\>1.5 nmol/l) or a serum digitoxin of \>20 ng/ml (\>26.2 nmol/l) at the Randomization Visit are excluded. A target serum digoxin level of \<=1.0 ng/ml (\<=1.3 nmol/l) is recommended
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time from randomization to all-cause mortality or cardiovascular hospitalization | Baseline to Month 6 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Patient Global Assessment score | Baseline to Month 6 | Improvement in quality of life assessed by the Patient Global Assessment patient-reported outcomes tool |
| Change in Six-Minute Walk Test | Baseline to Month 6 | Improvement in quality of life assessed by the Six-Minute Walk Test, a measure of submaximal exercise tolerance |
Outcome results
None listed