Sickle Cell Disease
Conditions
Keywords
DNA, Endothelial Function, Leukocyte Gene Expression, RNA, Natural History, Sickle Cell, Coronary Artery Disease, CAD, Healthy Volunteer, HV
Brief summary
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies. This protocol defines the purposes for which specimens will be collected and establishes general conditions under which sample collection will be performed....
Detailed description
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies. This protocol defines the purposes for which specimens will be collected and establishes general conditions under which sample collection will be performed.
Interventions
None listed
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* INCLUSION CRITERIA: Males or females of age 18 years and older can be included in the study.
Exclusion criteria
Individuals without sickle cell disease or other chronic anemias who wish to donate blood will be excluded if the hemoglobin is less than 10 g/dL for women or less than 12g/dL for men. Individuals with sickle cell disease or other chronic anemias will be excluded from donating blood samples if the hemoglobin is less than 6 g/dL. A participant s most recent CBC result, obtained in the past 12 months, will be used to determine eligibility. There are no
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluating the role of nitric oxide, inflammatory mediators, and endothelial function in inflammatory diseases of the vasculature such as sickle cell disease, coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and sep... | — |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORSwee Lay Thein, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
Outcome results
None listed