Lung Cancer
Conditions
Keywords
limited stage small cell lung cancer
Brief summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. Vaccines may make the body build an immune response to kill tumor cells. Combining chemotherapy and radiation therapy with vaccine therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy and radiation therapy with vaccine therapy in treating patients who have limited-stage small cell lung cancer.
Detailed description
OBJECTIVES: * Determine the efficacy of cisplatin, etoposide, and thoracic radiotherapy followed by cisplatin, etoposide, monoclonal antibody 11D10 anti-idiotype vaccine (TriAb), and monoclonal antibody GD2 anti-idiotype vaccine (TriGem), in terms of overall and progression-free survival of patients with limited stage small cell lung cancer. * Determine the immune response to each of the 2 anti-idiotype vaccines when used in this regimen in these patients. * Determine the qualitative and quantitative toxicity of this regimen in these patients. * Determine the response rates (confirmed and unconfirmed, complete and partial) in patients with measurable disease treated with this regimen. OUTLINE: This is a multicenter study. * Induction therapy: Patients receive cisplatin IV over 1 hour on days 1, 8, 29, and 36 and etoposide IV over 1 hour on days 1-5 and 29-33. Thoracic radiotherapy is administered 5 days a week, beginning on day 1 of chemotherapy, for 5 weeks. Patients then undergo radiotherapy boost for 1.5 weeks. Patients with stable disease or at least partial response proceed to consolidation therapy. * Consolidation therapy (begins within 3-5 weeks of the last dose of induction chemotherapy or radiotherapy): Patients receive cisplatin IV over 1 hour on day 1 and etoposide IV over 1 hour on days 1-3 of weeks 11 and 14. Patients also receive monoclonal antibody 11D10 anti-idiotype vaccine (TriAb) and monoclonal antibody GD2 anti-idiotype vaccine (TriGem) intradermally on day 1 of weeks 11, 13, 15, and 17 (4 injections) and then monthly subcutaneously for 2 years. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients who achieve complete response after consolidation chemotherapy undergo cranial radiotherapy 5 days a week for 3 weeks. Patients are followed every 3 months for 2 years and then every 6 months for 3 years. PROJECTED ACCRUAL: A total of 90 patients will be accrued for this study within 18 months.
Interventions
BIOLOGICALmonoclonal antibody GD2 anti-idiotype vaccine
DRUGcisplatin
DRUGetoposide
RADIATIONradiation therapy
Sponsors
National Cancer Institute (NCI)
SWOG Cancer Research Network
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed limited stage small cell lung cancer (SCLC) * Evidence of disease by CT scan of the chest * Measurable or evaluable disease outside of area of prior surgical resection * No malignant pericardial or pleural effusions (cytologically positive effusions or exudative effusions not attributable to other etiologies) * No CNS disease by chest CT scan or MRI PATIENT CHARACTERISTICS: Age * 18 and over Performance status * Zubrod 0-1 Life expectancy * Not specified Hematopoietic * Absolute neutrophil count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 Hepatic * Not specified Renal * Creatinine no greater than upper limit of normal OR * Creatinine clearance at least 60 mL/min Other * No prior hypersensitivity or contraindication to monoclonal antibody 11D10 anti-idiotype vaccine (TriAb), monoclonal antibody GD2 anti-idiotype vaccine (TriGem), or aluminum hydroxide * No known sensitivity to rodent proteins (i.e., anti-OKT-3, ONCOSCINT scan) * No grade 1 or greater symptomatic sensory neuropathy * No other malignancy except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, adequately treated stage I or II cancer in complete remission, or any other cancer for which patient has been disease free for 5 years * If significant clinical hearing loss already present, must accept risk of further hearing loss * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy * No prior biologic therapy for SCLC * No prior TriAb or TriGem * No prior murine antibodies * No prior mouse proteins * At least 30 days since prior immunotherapy * At least 30 days since any prior immunization Chemotherapy * No prior systemic chemotherapy for SCLC * No concurrent cyclophosphamide or methotrexate Endocrine therapy * At least 30 days since prior systemic corticosteroids * No concurrent systemic corticosteroids (except as an antiemetic) Radiotherapy * No prior radiotherapy to the thorax or neck region * No concurrent intensity modulated radiotherapy Surgery * See Disease Characteristics * At least 2 weeks since prior thoracic or other major surgery and recovered Other * At least 30 days since prior investigational agents or devices * No other concurrent investigational agents * No other concurrent immunosuppressants (e.g., cyclosporine) * No concurrent chronic systemic antihistamines * No concurrent amifostine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| overall survival | up to 5 years | time from date of registration to date of death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| immune response | at Week 10 | T-cell proliferation and HAMA testing |
| toxicity assessment | 22 weeks | assessment of qualitative and quantitative toxicities |
| response | 25 weeks | RECIST partial and complete response |
Countries
Canada, United States
Outcome results
None listed