Aplastic Anemia, Leukemia, Non Hodgkin's Lymphoma
Conditions
Keywords
Lymphoma, CML, CLL, AML, ALL, MDS, AA
Brief summary
The purpose of this study is to assess early treatment failure within 100 days and to assess the effect of this regimen on engraftment, GVHD, immune recovery, relapse of malignancy and survival.
Interventions
PROCEDUREMegadose T-cell Depleted HLA-nonidentical Blood Progenitor Cell Transplantation
Sponsors
M.D. Anderson Cancer Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 49 Years
Healthy volunteers
No
Inclusion criteria
* Patients with acute leukemia, lymphoma that failed to respond or relapsed after chemotherapy or CML beyond first chronic phase. * Patients with aplastic anemia or myelodysplasia which failed to respond to primary therapy are eligible. * Patients with low grade lymphoma or CLL will only be eligible if they failed two chemotherapy regimens and have stage IV disease. * Patients must be \<age 50 with a related haploidentical donor (phenotypically one, two or three HLA A, B and DR antigen mismatched) donor. * Patients should have adequate hepatic and renal function with a bilirubin of less than or equal to 1.5mg%, SGPT less than or equal to 3x the upper limits of normal, and creatine less than or equal to 1.5mg%. * Patients with serious intercurrent medical illness are not eligible. * Patients and their donors must provide written informed consent.
Countries
United States
Outcome results
None listed