Bacterial Infections, Gram-Positive Bacterial Infections, Bacteremia
Conditions
Brief summary
This study will treat patients who have a short term central catheter that is thought to be infected with a specific bacteria (gram positive bacteria)
Interventions
Sponsors
Pfizer
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
13 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with a central indwelling catheter with signs and symptoms of infection
Exclusion criteria
* Patients with tunneled catheter which cannot be removed. * Patients with evidence of endovascular infection including endocarditis. * Patients with infection of permanent intravascular devices. * Patients who have received more than 1 day of another antibiotic before enrollment. * Patients with HIV and low CD4 count.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The empiric treatment of patients with complicated skin and skin structure infections (cSSSI) related to an indwelling catheter; | — |
| The empiric treatment of patients with gram-positive catheter-related bloodstream infections. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical efficacy of linezolid compared to vancomycin/oxacillin/dicloxacillin.2.Incidence of late metastatic sequelae associated with S. aureus infections in patients treated with linezolid | — |
Outcome results
None listed