Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Depression, Fatigue, Quality of Life
Conditions
Keywords
fatigue, depression, quality of life, cognitive/functional effects, recurrent adult brain tumor, adult brain stem glioma, adult glioblastoma, adult tumors metastatic to brain, adult anaplastic astrocytoma, adult anaplastic oligodendroglioma, adult mixed glioma, adult meningioma, adult anaplastic ependymoma, adult myxopapillary ependymoma, adult ependymoblastoma, adult pilocytic astrocytoma, adult subependymoma, adult grade III meningioma, adult giant cell glioblastoma, adult gliosarcoma, adult grade II meningioma
Brief summary
RATIONALE: Methylphenidate may decrease side effects of radiation therapy. It is not yet known if methylphenidate is effective in improving quality of life in patients with primary or metastatic brain tumors. PURPOSE: Randomized phase III trial to determine the effectiveness of methylphenidate in improving quality of life in patients who have brain tumors and are undergoing radiation therapy.
Detailed description
OBJECTIVES: * Determine the effect of d-methylphenidate on fatigue in patients receiving radiotherapy for primary or metastatic brain tumors. * Determine the effect of this drug on the quality of life of these patients. * Determine the effect of this drug on depression in these patients. * Determine the effect of this drug on global neurocognitive function, including attention and concentration, memory, language, visuospatial skills, and executive function, in these patients. OUTLINE: This is a randomized, placebo-controlled, double-blind, multicenter study. Patients are stratified by tumor type (primary vs metastatic), treatment (radiotherapy vs radiotherapy and chemotherapy), and Karnofsky performance status (70% or 80% vs 90% or 100%). Patients are randomized to one of two treatment arms. All patients undergo radiotherapy over weeks 1-4. * Arm I: Patients receive oral d-methylphenidate twice daily on weeks 1-12. * Arm II: Patients receive oral placebo twice daily on weeks 1-12. In both arms, quality of life is assessed at baseline, at the end of radiotherapy, and at 4, 8, and 12 weeks after radiotherapy. Patients are followed at 4 weeks. PROJECTED ACCRUAL: A total of 200 patients (100 per treatment arm) will be accrued for this study within 18 months.
Interventions
DRUGmethylphenidate hydrochloride
PROCEDUREquality-of-life assessment
RADIATIONradiation therapy
Sponsors
National Cancer Institute (NCI)
Wake Forest University Health Sciences
Study design
Allocation
RANDOMIZED
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 120 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically confirmed metastatic brain tumor OR * Histologically confirmed primary brain tumor * Glioblastoma multiforme * Anaplastic astrocytoma * Anaplastic oligodendroglioma * Anaplastic mixed oligoastrocytoma * Low-grade glioma * Meningioma * Ependymoma * Planned external beam cranial radiotherapy (partial or whole brain) with a total dose of at least 25 Gy in at least 10 fractions of 180-300 cGy each PATIENT CHARACTERISTICS: Age: * 18 and over Performance status: * Karnofsky 70-100% Life expectancy: * At least 3 months Hematopoietic: * WBC ≥ 1,500/mm\^3 * Hemoglobin ≥ 10.0 g/dL * Platelet count ≥ 75,000/mm\^3 Hepatic: * Not specified Renal: * Not specified Cardiovascular: * No hypertension or other cardiovascular disease requiring antihypertensives and/or other cardiovascular medications Other: * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No other serious medical or psychiatric illness that would preclude study participation * No hypersensitivity to study drug * No history of steroid psychosis * No family history of or active Tourette's Syndrome * No prior or active glaucoma PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * Prior or concurrent chemotherapy allowed Endocrine therapy: * Concurrent steroids allowed Radiotherapy: * See Disease Characteristics * Prior radiotherapy allowed except to brain (including stereotactic radiosurgery) * No concurrent craniospinal axis radiotherapy Surgery: * Not specified Other: * No prior or concurrent medications for attention deficit disorder, anxiety disorder, schizophrenia, or substance abuse * No concurrent anti-depressants
Countries
United States
Outcome results
None listed