Treating Alcohol Use In Older Adults With Depression

The Treatment of Late Life Major Depression Complication by Alcohol

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00018824

Enrollment

Registered

2001-07-05

Start date

1999-10-31

Completion date

2005-01-31

Last updated

2009-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcoholism, Depression

Brief summary

The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.

Detailed description

This study aims to study 80 patients with comorbid alcohol dependence and a depressive syndrome. After appropriate detoxification, patients are started on either naltrexone 50 mg or placebo. After one week, sertraline is added in an open label fashion. It is hypothesized that those patients receiving combination therapy will last 3 months with follow-up tracking lasting 1 year.

Interventions

DRUGNALTREXONE

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

55 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 55 * Current depressive syndrome * Current alcohol dependence * No psychosis * No opioid or cocaine abuse or dependence

Design outcomes

Primary

Measure	Time frame
Alcohol use'	12 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026