Genotype Influence on Recovery After Traumatic Brain Injury

The Influence of APOE Genotype on Recovery After Traumatic Brain Injury

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00018499

Enrollment

Unknown

Registered

2001-07-05

Start date

1998-10-31

Completion date

2001-10-31

Last updated

2009-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Injury

Keywords

Traumatic Brain Injury

Brief summary

Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.

Detailed description

Polymorphisms in the Apolipoprotein E gene encode functional variants which differentially determine the rate at which neuronal repair can occur, and are associated with differences in expression of neurodegenerative processes, including traumatic brain injury. It is proposed that the accuracy of prediction of outcome after head injury will be significantly increased by inclusion of APOE genotype alone, or in combination with other variables such as severity of head injury, cognitive, electroencephalographic or neuroradiologic measures, or treatment strategies.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

17 Years to 55 Years

Healthy volunteers

Inclusion criteria

Patients enrolled in the DVHIP are subject to the following recruitment criteria: 1. Mild, moderate or severe closed head injury, where the cut off between mild and moderate is defined by GCS\<12. PTA\>24 hrs or - foca cerebral contusion on CT/MRI or Loss of Consciousness (LOC) \> 12 hours. Note: the definition of mild, moderate or severe head injury differs widely between centers and is absolutely not critical for the work proposed as we will use continuous measures of severity throughout. 2. Within three months of first assessment. (In practice, patients may be recruited after 3 months. We will deal with this issue by covarying the time from injury to first assessment in our analyses). 3. Rancho Los Amigos cognitive level of 5-7 at first assessment. 4. Volunteer informed consent signed by patient of family. 5. Military or veterans health care beneficiary. 6. Age 17-55

Exclusion criteria

1. Unwillingness to participate in rehabilitation program or cooperate with investigators. 2. History of prior severe traumatic brain injury of other severe neurologic or psychiatric condition, such as psychosis, stroke, multiple sclerosis, or spinal cord injury.

Countries

United States

Outcome results