Prepulse Inhibition of Startle in Cocaine Dependence - 7

Prepulse Inhibition of Startle in Cocaine Dependence (Human)

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00015249

Enrollment

Registered

2001-04-18

Start date

1997-02-28

Completion date

1998-05-31

Last updated

2017-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cocaine-Related Disorders, Substance-Related Disorders

Keywords

cocaine dependence

Brief summary

The purpose of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.

Detailed description

The objective of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.

Interventions

DRUGAmantadine

Study design

Primary purpose

DIAGNOSTIC

Masking

DOUBLE

Eligibility

Sex/Gender

MALE

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

Cocaine dependence. Male. Right handed. Negative urine for cocaine

Exclusion criteria

Positive urine for cocaine. History of head trauma. Significant medical disease.

Design outcomes

Primary

Measure	Time frame
Percent prepulse inhibition	—
Cocaine assessment	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026